Hepatocellular Carcinoma Market 2024: Opportunity Analysis and Forecasts
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- Opportunity Analysis and Forecasts to 2024 provides information on
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About
Hepatocellular Carcinoma Market
Liver cancer is the second leading
cause of cancer related death in the world in men and the sixth
leading cause of cancer death in women. Hepatocellular carcinoma
(HCC) is the most dominant form of liver cancer, accounting for
approximately 85% of liver cancer cases. The prognosis of HCC is
dependent on the stage of the disease at diagnosis. However, even
with treatments such as surgical resection, liver transplantation,
and ablative therapies, which are only suitable for early-stage HCC
patients, the majority of patients are likely to progress onto the
advanced stages of the disease.
Highlights
Key Questions Answered
Nexavar, approved in 2007, is the
only available targeted treatment option for patients with advanced
HCC and has dominated the HCC market in the seven major markets (7MM:
US, France, Germany, Italy, Spain, UK, and Japan) since its launch.
The current late and early stage
pipeline is very strong and diverse. Which drug will have the biggest
impact on the market? What strategies are developers undertaking to
overcome the high risk of clinical trial failure?
Nexavar will lose patent
protection within the forecast period. How will this impact the HCC
market and will new market entries be able to stabilize the HCC
market?
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Table of Contents
1 Table of Contents 9
1.1 List of Tables 14
1.2 List of Figures 18
2 Introduction 20
2.1 Catalyst 20
2.2 Related Reports 21
2.3 Upcoming Reports 21
3 Disease Overview 22
3.1 Etiology and Pathophysiology
23
3.1.1 Etiology 23
3.1.2 HBV Infection 24
3.1.3 HCV Infection 24
3.2 Surveillance of HCC 25
3.3 Alpha-Fetoprotein and other
Biomarkers 27
3.4 Pathophysiology 28
3.5 Clinical Staging and Treatment
Guidelines 29
3.6 Prognosis and Progression 33
4 Epidemiology 34
4.1 Disease Background 34
4.2 Risk Factors and Comorbidities
35
4.3 Global Trends 37
4.3.1 Incidence 37
4.3.2 Relative Survival 38
4.3.3 Stage at Diagnosis 40
4.4 Forecast Methodology 41
4.4.1 Sources Used 46
4.4.2 Sources Not Used 49
4.4.3 Forecast Assumptions and
Methods 50
4.5 Epidemiological Forecast of
HCC (2014-2024) 53
4.5.1 Diagnosed Incident Cases of
HCC 53
4.5.2 Age-Specific Diagnosed
Incident Cases of HCC 55
4.5.3 Sex-Specific Diagnosed
Incident Cases of HCC 56
4.5.4 Age-Standardized Diagnosed
Incidence of HCC 58
4.5.5 Diagnosed Incident Cases of
HCC by BCLC Stages 59
4.5.6 Diagnosed Incident Cases of
HCC with HBV and HCV Comorbidities 61
4.5.7 Five-Year Diagnosed
Prevalent Cases of HCC 63
4.6 Discussion 65
4.6.1 Epidemiological Forecast
Insight 65
4.6.2 Limitations of the Analysis
66
4.6.3 Strengths of the Analysis 67
5 Current Treatment Options 68
5.1 Overview 68
5.2 Product Profiles - Major
Brands 70
5.2.1 Nexavar (sorafenib) 70
5.3 Therapy Approaches 75
5.3.1 Early-Stage HCC Treatment 75
5.3.2 Intermediate and
Advanced-Stage HCC Treatment 80
5.4 Other Treatments 85
5.4.1 Adjunctive Therapy and
Treatment of Underlying Diseases 85
5.4.2 Systemic Chemotherapy 85
5.4.3 Radiation Therapy 86
6 Unmet Needs Assessment and
Opportunity Analysis 87
6.1 Overview 87
6.2 Unmet Needs Analysis 87
6.2.1 Improved Treatability of
Late-Stage HCC (First and Second Line) 87
6.2.2 Better Prognostic Biomarkers
89
6.2.3 Safe and Efficacious
Adjuvant and Neoadjuvant Therapies 91
6.2.4 Better HCC Surveillance and
Prophylactic Treatments 94
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7 R&D Strategies 97
7.1 Overview 97
7.2 Treatments for
Nexavar-Refractory Patients 97
7.3 C-Met as a Molecular Target
for HCC as well as a Potential Biomarker 98
7.4 HCC as an Add-on Indication
for Marketed Products 98
7.5 Multi-kinase Inhibitors Remain
Well Represented in the Early- and Late-Stage Pipeline 98
7.6 Clinical Trial Design 99
7.6.1 Clinical Trial Failures
2007-2015 99
7.6.2 HCC Phase III Clinical Trial
Design 2015 101
7.6.3 Clinical Trial Design
Cornerstones 103
8 Pipeline Assessment 105
8.1 Overview 105
8.2 Promising Drugs in Clinical
Development 106
8.2.1 Multi Kinase Inhibitors 107
8.2.2 Lenvima (lenvatinib) 108
8.2.3 Stivarga (regorafenib) 114
8.2.4 Cometriq (cabozantinib) 119
8.2.5 Tivantinib (ARQ 197) 124
8.2.6 Pexa-Vec (pexastimogene
devacirepvec) 132
8.2.7 Cyramza (ramucirumab) 136
8.2.8 Pegargiminase (ADI-PEG 20)
143
8.2.9 Livatag (doxorubicin
Transdrug) 147
8.2.10 ThermoDox (Heat-Activated
Liposomal Encapsulation of Doxorubicin) 151
8.2.11 Peretinoin (polyprenoic
acid) 156
8.3 Innovative Early-Stage
Approaches 161
8.3.1 Overview 161
8.3.2 Immunotherapies 163
9 Pipeline Valuation Analysis 167
9.1 Overview 167
9.2 Clinical Benchmark of Key
Pipeline Drugs 168
9.2.1 First-Line Therapy for
Patients with Advanced HCC 168
9.2.2 Second-Line Therapy for
Patients with Advanced HCC 169
9.2.3 Adjunctive Therapy Following
Resection/Ablation or RFA 172
9.3 Commercial Benchmark of Key
Pipeline Drugs 173
9.3.1 First-Line Therapy for
Patients with Advanced HCC 173
9.3.2 Second-Line Therapy for
Patients with Advanced HCC 174
9.3.3 Adjunctive Therapy Following
Resection/Ablation or RFA 176
9.4 Competitive Assessment 178
9.4.1 First-Line and Second-Line
Therapy for Patients with Advanced HCC 178
9.4.2 Adjunctive Therapy Following
Resection/Ablation or RFA 180
9.5 Top-Line 10-Year Forecast 182
9.5.1 US 185
9.5.2 5EU 187
9.5.3 Japan 188
10 Appendix 189
10.1 Bibliography 189
10.2 Abbreviations 212
10.3 Methodology 216
10.4 Forecasting Methodology 216
10.4.1 HCC Incidence Patients 216
10.4.2 Progression 217
10.4.3 Percent Drug-Treated
Patients 219
10.4.4 Drugs Included in Each
Therapeutic Class and Patient Distributions Not Included in HCC Sales
219
10.4.5 Launch and Patent Expiry
Dates 221
10.4.6 General Pricing Assumptions
222
10.4.7 Individual Drug and
Pipeline Assumptions 223
10.4.8 Generic Erosion 230
10.5 Physicians and Specialists
Included in this Study 231
10.5.1 Primary Research -
Prescriber Survey 232
10.6 About the Authors 233
10.6.1 Author 233
10.6.2 Reviewer 233
10.6.3 Epidemiologists 234
10.6.4 Global Head of Healthcare
235
10.7 About GlobalData 236
10.8 Disclaimer 236
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